Side Effects of Chemotherapy

  1. CHEMOTHERAPY DECREASES RED BLOOD CELLS (ANEMIA): Mountzios G, Aravantinos G, Alexopoulou Z, et al. Lessons from the past: Long-term safety and survival outcomes of a prematurely terminated randomized controlled trial on prophylactic vs. hemoglobin-based administration of erythropoiesis-stimulating agents in patients with chemotherapy-induced anemia. Mol Clin Oncol. 2016;4(2):211-220. 
  2. CHEMOTHERAPY DECREASES WHITE BLOOD CELLS (LEUKOPENIA): Li DY, Yu TT, Bai H, Chen XY. [Clinical study on effect of compound granule prescription of thunberg fritillary bulb in relieving post-chemotherapy bone marrow suppression in RAL patients]. Zhongguo Zhong Yao Za Zhi. 2012;37(20):3155-7. 
  3. CHEMOTHERAPY DECREASES BLOOD PLATELETS: Tamamyan G, Danielyan S, Lambert MP. Chemotherapy induced thrombocytopenia in pediatric oncology. Crit Rev Oncol Hematol. 2016;99:299-307. 
  4. CHEMOTHERAPY CAUSES BONE DEATH(OSTEONECROSIS): Antonuzzo L, Lunghi A, Giommoni E, Brugia M, Di costanzo F. Regorafenib Also Can Cause Osteonecrosis of the Jaw. J Natl Cancer Inst. 2016;108(4). 
  5. CHEMOTHERAPY CAUSES LOSS OF BONE MINERAL DENSITY (OSTEOPOROSIS): Bordbar MR, Haghpanah S, Dabbaghmanesh MH, Omrani GR, Saki F. Bone mineral density in children with acute leukemia and its associated factors in Iran: a case-control study. Arch Osteoporos. 2016;11(1):36. 
  6. CHEMOTHERAPY CAUSES LOSS OF BONE MINERAL DENSITY (OSTEOPOROSIS):Lee SW, Yeo SG, Oh IH, Yeo JH, Park DC. Bone mineral density in women treated for various types of gynecological cancer. Asia Pac J Clin Oncol. 2016; 
  7. CHEMOTHERAPY IS TOXIC TO THE BRAIN: Matsuoka A, Mitsuma A, Maeda O, et al. Quantitative assessment of chemotherapy-induced peripheral neurotoxicity using a point-of-care nerve conduction device. Cancer Sci. 2016;107(10):1453-1457. 
  8. CHEMOTHERAPY CAUSES LONGTERM IMPAIRMENT OF CONCENTRATION, FORGETFULNESS AND SLOWER THINKING (CHEMOBRAIN): Iarkov A, Appunn D, Echeverria V. Post-treatment with cotinine improved memory and decreased depressive-like behavior after chemotherapy in rats. Cancer Chemother Pharmacol. 2016;78(5):1033-1039. 
  9. CHEMOTHERAPY CAUSES LONGTERM IMPAIRMENT OF CONCENTRATION, FORGETFULNESS AND SLOWER THINKING (CHEMOBRAIN): Rendeiro C, Sheriff A, Bhattacharya TK, et al. Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer. Behav Brain Res. 2016;315:10-22. 
  11. CHEMOTHERAPY DECREASES EMOTIONAL AND SOCIAL FUNCTION AND INCREASE DISTRESS: Dunn J, Watson M, Aitken JF, Hyde MK. Systematic Review of Psychosocial Outcomes for Patients with Advanced Melanoma. Psychooncology. 2016; 
  12. CHEMOTHERAPY CAUSES DEPRESSION: Oh PJ, Lee JR. [Effect of Cancer Symptoms and Fatigue on Chemotherapy-related Cognitive Impairment and Depression in People with Gastrointestinal Cancer). J Korean Acad Nurs. 2016;46(3):420-30. 
  13. CHEMOTHERAPY CAUSES ANXIETY: Baek Y, Yi M. [Factors Influencing Quality of Life during Chemotherapy for Colorectal Cancer Patients in South Korea). J Korean Acad Nurs. 2015;45(4):604-12. 
  14. CHEMOTHERAPY CAUSES SERVERE DENTAL CARIES: Peretz B, Sarnat H, Kharouba J. Chemotherapy induced dental changes in a child with medulloblastoma: a case report. J Clin Pediatr Dent. 2014;38(3):251-4. 
  15. CHEMOTHERAPY CAUSES ORAL DANDIDA (FUNGAL) INFECTION: Alt-epping B, Nejad RK, Jung K, Gross U, Nauck F. Symptoms of the oral cavity and their association with local microbiological and clinical findings–a prospective survey in palliative care. Support Care Cancer. 2012;20(3):531-7.
  16. CHEMOTHERAPY CAUSES PAINFUL INFLAMMATION AND ULCERATION IN THE MOUTH (ORAL MUCOSITIS):Dreizen S, Mccredie KB, Keating MJ. Chemotherapyinduced oral mucositis in adult leukemia. Postgrad Med. 1981;69(2):103-8, 111-2. 
  17. CHEMOTHERAPY CAUSES A DIVERSE SPECTRUM OF ORAL CHANGES THAT GENERALLY ARE ATTRIBUTED TO IMMUNOSUPPRESSION AND BLEEDING TENDENCIES: Farsi DJ. Children Undergoing Chemotherapy: Is It Too Late for Dental Rehabilitation?. J Clin Pediatr Dent. 2016;40(6):503-505. 
  18. CHEMOTHERAPY CAUSES DIARHHEA: Abalo R, Uranga JA, Pérez-garcía I, et al. May cannabinoids prevent the development of chemotherapy-induced diarrhea and intestinal mucositis? Experimental study in the rat. Neurogastroenterol Motil. 2016. 
  19. CHEMOTHERAPY CAUSES SIGNIFICANT INTESTINAL DAMAGE IN BOTH JEJUNUM AND COLON: Forsgård RA, Korpela R, Holma R, et al. Intestinal permeability to iohexol as an in vivo marker of chemotherapy-induced gastrointestinal toxicity in SpragueDawley rats. Cancer Chemother Pharmacol. 2016;78(4):86374. 
  20. CHEMOTHERAPY REDUCES GRIP STRENGTH: Klepin HD, Tooze JA, Pardee TS, et al. Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia. J Am Geriatr Soc. 2016;64(10):1988-1995. 
  21. CHEMOTHERAPY CAUSES MUSCLE DYSFUNCTION AND A LOSS OF OVERALL STRENGTH: Gilliam LA, Lark DS, Reese LR, et al. Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Endocrinol Metab. 2016;311(2):E293-301.
  22. CHEMOTHERAPY CAUSES SEVERE VISION LOSS AND ALTERED COLORVISION: Giralt J, Rey A, Villanueva R, Alforja S, Casaroli-marano RP. Severe visual loss in a breast cancer patient on chemotherapy. Med Oncol. 2012;29(4):2567-9.
  23. CHEMOTHERAPY CAUSES COMPLETE BLINDNESS: Cloutier AO. Ocular side effects of chemotherapy: nursing management. Oncol Nurs Forum. 1992;19(8):1251-9. 
  24. CHEMOTHERAPY CAUSES INFERTILITY AND PREMATURE OVARIAN FAILURE: Batchvarov IS, Taylor RW, Bustamante-marín X, et al. A grafted ovarian fragment rescues host fertility after chemotherapy. Mol Hum Reprod. 2016. 
  25. CHEMOTHERAPY CAUSES INFERTILITY AND PREMATURE OVARIAN FAILURE: Clowse ME, Behera MA, Anders CK, et al. Ovarian preservation by GnRH agonists during chemotherapy: a meta-analysis. J Womens Health (Larchmt). 2009;18(3):3119. 
  26. CHEMOTHERAPY CAUSES INFERTILITY AND PREMATURE OVARIAN FAILURE IN UPTO 66% OF WOMEN: Garrido-oyarzun MF, Castelo-branco C. Controversies over the use of GnRH agonists for reduction of chemotherapyinduced gonadotoxicity. Climacteric. 2016;19(6):522-525. 
  27. CHEMOTHERAPY CAUSES ABSENCE OF MENSTRUAL PERIOD (AMENORRHEA) AND MENOPAUSAL SYMPTOMS: Li CY, Chen ML. [Chemotherapy-Induced Amenorrhea and Menopause Symptoms in Women With Breast Cancer). Hu Li Za Zhi. 2016;63(5):19-26. 
  28. CHEMOTHERAPY CAUSES DAMAGE TO SPERM AND TESTICULAR TISSUE, CHEMOTHERAPY REDUCES REPRODUTCTIVE ORGAN WEIGHT; SPERM COUNT AND SPERM MOTILITY: Eid AH, Abdelkader NF, Abd el-raouf OM, Fawzy HM, Eldenshary ES. Carvedilol alleviates testicular and spermatological damage induced by cisplatin in rats via modulation of oxidative stress and inflammation. Arch Pharm Res. 2016. 
  29. CHEMOTHERAPY CAUSES DAMAGE TO SPERM AND TESTICULAR TISSUE: Levi M, Popovtzer A, Tzabari M, et al. Cetuximab intensifies cisplatin-induced testicular toxicity. Reprod Biomed Online. 2016;33(1):102-10.
  30. CHEMOTHERAPY CAUSES HAIRLOSS: Trüeb RM. Chemotherapy-induced alopecia. Semin Cutan Med Surg. 2009;28(1):11-4.
  31. CHEMOTHERAPY IMPAIRS WOUND HEALING: Tanaka S, Hayek G, Jayapratap P, et al. The Impact of Chemotherapy on Complications Associated with Mastectomy and Immediate Autologous Tissue Reconstruction. Am Surg. 2016;82(8):713-7. 
  32. CHEMOTHERAPY CAUSES SEVERE TO PROFOUND HEARING LOSS: Frisina RD, Wheeler HE, Fossa SD, et al. Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of AdultOnset Cancer. J Clin Oncol. 2016;34(23):2712-20. 
  33. CHEMOTHERAPY CAUSES DAMAGE TO HEART: Truong J, Yan AT, Cramarossa G, Chan KK. Chemotherapy induced cardiotoxicity: detection, prevention, and management. Can J Cardiol. 2014;30(8):869-78. 
  34. CHEMOTHERAPY CAUSES HEART DISEASE: Granger CB. Prediction and prevention of chemotherapy induced cardiomyopathy: can it be done?. Circulation. 2006;114(23):2432-3. 
  35. CHEMOTHERAPY CAUSES HEART FAILURE: Smith SA, Auseon AJ. Chemotherapy-induced takotsubo cardiomyopathy. Heart Fail Clin. 2013;9(2):233-42. 
  36. CHEMOTHERAPY CAUSES HEART ATTACK (MYOCARDIAL INFARCTION): Sakka S, Kawai K, Tsujimoto I, et al. [Severe Acute Myocardial Infarction during Induction Chemotherapy for Retroperitoneal Germ Cell Tumor : A Case Report]. Hinyokika Kiyo. 2016;62(9):483-487. 
  37. CHEMOTHERAPY CAUSES LONG TERM DAMAGE TO IMMUNE SYSTEM: Perkins JL, Harris A, Pozos TC. Immune Dysfunction After Completion of Childhood Leukemia Therapy. J Pediatr Hematol Oncol. 2016. 
  38. CHEMOTHERAPY CAUSES LONG TERM DAMAGE TO IMMUNE SYSTEM: Verma R, Foster RE, Horgan K, et al. Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Res. 2016;18(1):10. 
  39. CHEMOTHERAPY EXERBATES EXISTING HEPATITIS C INFECTIONS: Lin JW, Chang ML, Hsu CW, et al. Acute exacerbation of hepatitis C in hepatocellular carcinoma patients receiving chemotherapy. J Med Virol. 2017;89(1):153-160. 
  40. CHEMOTHERAPY REACTIVATES HEPATITIS B VIRUS: Qin L, Wang F, Zou BW, Ding ZY. Chemotherapy-induced fatal hepatitis B virus reactivation in a small-cell lung cancer patient. Mol Clin Oncol. 2016;5(4):382-384.
  41. CHEMOTHERAPY IMPAIRS ANTI-TUMOR IMMUNE RESPONSE: Wu Y, Deng Z, Wang H, Ma W, Zhou C, Zhang S. Repeated cycles of 5-fluorouracil chemotherapy impaired anti-tumour functions of cytotoxic T cells in a CT26 tumour-bearing mouse model. BMC Immunol. 2016;17(1):29. 
  42. CHEMOTHERAPY CAUSES KIDNEY FAILURE: Dugbartey GJ, Peppone LJ, De graaf IA. An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures. Toxicology. 2016;371:58-66. 
  43. CHEMOTHERAPY CAUSES LIVER INJURY: Hiroshima Y, Shuto K, Yamazaki K, et al. Fractal Dimension of Tc-99m DTPA GSA Estimates Pathologic Liver Injury due to Chemotherapy in Liver Cancer Patients. Ann Surg Oncol. 2016;23(13):4384-4391. 
  44. CHEMOTHERAPY CAUSES LUNG DISEASE: Limper AH. Chemotherapy-induced lung disease. Clin Chest Med. 2004;25(1):53-64.
  45. CHEMOTHERAPY CAUSES DRY MOUTH (XEROSTOMIA), ULCERS AND MOUTH SORES: Berger velten D, Zandonade E, Monteiro de barros miotto MH. Prevalence of oral manifestations in children and adolescents with cancer submitted to chemotherapy. BMC Oral Health. 2016;16(1):107. 
  46. CHEMOTHERAPY CAUSES NEUROPATHIC PAIN; BURNING OR COLDNESS, PINS AND NEEDLES SENSATIONS, NUMBNESS AND ITCHING: Gong SS, Li YX, Zhang MT, et al. Neuroprotective Effect of Matrine in Mouse Model of Vincristine-Induced Neuropathic Pain. Neurochem Res. 2016;41(11):3147-3159. 
  47. CHEMOTHERAPY PAIN REMAINS ONE YEAR AFTER TREATMENT: Hellerstedt-börjesson S, Nordin K, Fjällskog ML, Holmström IK, Arving C. Women Treated for Breast Cancer Experiences of Chemotherapy-Induced Pain: Memories, Any Present Pain, and Future Reflections. Cancer Nurs. 2016;39(6):464472. 
  48. CHEMOTHERAPY CAUSES DIFFICULTY IN SWALLOWING (DYSPHAGIA): Mcnamara MJ, Adelstein DJ, Allende DS, et al. Persistent Dysphagia After Induction Chemotherapy in Patients with Esophageal Adenocarcinoma Predicts Poor Post-Operative Outcomes. J Gastrointest Cancer. 2016. 
  49. CHEMOTHERAPY CAUSES NAUSEA AND VOMITING (EMESIS): Fakhfouri G, Mousavizadeh K, Mehr SE, et al. From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 Receptor Antagonists. Mol Neurobiol. 2015;52(3):1670-9. 
  50. CHEMOTHERAPY CAUSES NAUSEA AND VOMITING (EMESIS): Thamlikitkul L, Srimuninnimit V, Akewanlop C, et al. Efficacy of ginger for prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adriamycin-cyclophosphamide regimen: a randomized, double-blind, placebo-controlled, crossover study. Support Care Cancer. 2016. 
  51. CHEMOTHERAPY CAUSES ALTERED TASTE SENSATION: Sozeri E, Kutluturkan S. The Validity and Reliability of Turkish Version of the Chemotherapy-induced Taste Alteration Scale (CITAS). Clin Nurs Res. 2016. 
  52. CHEMOTHERAPY CAUSES MIGRAINE HEADACHES: Rajasekhar A, George TJ. Gemcitabine-induced reversible posterior leukoencephalopathy syndrome: a case report and review of the literature. Oncologist. 2007;12(11):1332-5.